Application of Tubular Centrifuges in the Pharmaceutical Field
Introduction
The pharmaceutical industry has extremely high requirements for the purity, safety, and effectiveness of drugs. During the drug research and development and production processes, it is often necessary to process complex biological samples and chemical solutions to separate and purify target components. As an efficient centrifugal separation device, the tubular centrifuge, with its unique working principle and significant advantages, plays a crucial role in the pharmaceutical field, providing key technical support for improving drug quality and accelerating the research and development process.
Product Parameters
Working Principle of Tubular Centrifuges
A tubular centrifuge mainly consists of a high - speed rotating slender drum, a driving device, a feeding system, and a discharging system. Its operation is based on the principle of centrifugal sedimentation. When the mixed liquid containing drug components or impurities to be processed enters the high - speed rotating drum (the rotational speed usually can reach 15,000 - 50,000 revolutions per minute or even higher) through the feeding port, under the action of a strong centrifugal force field, due to the density differences among different substances, particles or target components with higher density are subjected to a greater centrifugal force and rapidly move towards the drum wall and settle, while the liquid phase with lower density stays closer to the center of the drum. Through a well - designed discharging device, the substances settled on the drum wall and the clear liquid near the center can be collected separately, thus achieving the effective separation of the mixture.
| Model |
GQ75 |
GQ105 |
GQ125 |
GQ150 |
| Drum Diameter |
75mm |
105mm |
125mm |
150mm |
| Rotating Speed of Drum |
19000rpm |
16300rpm |
15000rpm |
14000rpm |
| Centrifugal force |
15200G |
15620G |
15700G |
15600G |
| Capacity |
600L/H |
1200L/H |
1500L/H |
2500L/H |
| Motor |
1.5kw |
2.2KW |
3.0KW |
3.0KW |
| Weight |
300kg |
500kg |
550kg |
600kg |
Dimension |
760*450*1120mm |
840*500*1600mm |
900*550*1600mm |
950*600*1600mm |
We will provide one year's worth of accessories for free. And professional disassembly tools are also available.
Advantages of Tubular Centrifuges in the Pharmaceutical Field
High Separation Efficiency
- Rapid Sedimentation
The extremely high rotational speed of the tubular centrifuge generates a strong centrifugal force, which greatly accelerates the sedimentation speed of substances. When processing biological fermentation broth to extract drugs such as antibiotics, traditional gravity sedimentation may take several hours or even several days, while the tubular centrifuge can complete the separation of the same volume of liquid within a few minutes to dozens of minutes, greatly shortening the production cycle and improving production efficiency.
- Continuous Production
It has the functions of continuous feeding and discharging, which is suitable for large - scale industrial pharmaceutical production. When producing influenza vaccines, a large amount of virus cultures can be continuously fed into the tubular centrifuge, and the separated active ingredients and impurities can be continuously output. The whole process does not require frequent shutdowns, ensuring the continuity and stability of production and meeting the large - scale market demand for drugs.
High - Purity Products
- Effective Impurity Removal
It can accurately separate tiny impurity particles in the mixed liquid, such as microorganisms, cell debris, unreacted chemical substances, etc. If these impurities remain in the drug, they may affect the quality and safety of the drug. For example, when preparing biological drugs such as insulin, the tubular centrifuge can reduce the impurity content to an extremely low level, making the product purity reach over 99%, meeting the strict drug quality standards.
- Reduced Cross - Contamination
The relatively closed working environment inside the tubular centrifuge reduces the risk of contamination of drugs by external microorganisms and impurities. When producing sterile drugs, its closed drum and precise sealing device effectively prevent secondary contamination, ensuring the sterility and purity of drugs and improving the quality stability of drugs.
Application
A tubular centrifuge is mainly composed of a high - speed rotating slender drum, a driving device, a feeding system, and a discharging system. Its operation is based on the principle of centrifugal sedimentation. When the suspension containing spirulina enters the high - speed rotating drum (the rotational speed can usually reach 15,000 - 50,000 revolutions per minute or even higher) through the feeding port, under the action of a strong centrifugal force field, due to the density difference between spirulina cells and other components in the cultivation water (such as water, dissolved minerals, microorganisms, etc.), the spirulina cells are subjected to a relatively large centrifugal force and rapidly move towards the drum wall and settle. Meanwhile, the liquid phase with a lower density stays closer to the center of the drum. Through a well - designed discharging device, the spirulina settled on the drum wall can be collected, and the clear liquid is discharged from another outlet, thus achieving the effective separation of spirulina from the cultivation water.
High - Purity Products
- Effective Impurity Removal
It can accurately separate tiny impurity particles in the mixed liquid, such as microorganisms, cell debris, unreacted chemical substances, etc. If these impurities remain in the drug, they may affect the quality and safety of the drug. For example, when preparing biological drugs such as insulin, the tubular centrifuge can reduce the impurity content to an extremely low level, making the product purity reach over 99%, meeting the strict drug quality standards.
- Reduced Cross - Contamination
The relatively closed working environment inside the tubular centrifuge reduces the risk of contamination of drugs by external microorganisms and impurities. When producing sterile drugs, its closed drum and precise sealing device effectively prevent secondary contamination, ensuring the sterility and purity of drugs and improving the quality stability of drugs.
Gentle Separation Process
- Protection of Biological Activity
When processing biological products such as antibodies and enzymes, the shear force generated during the high - speed rotation of the tubular centrifuge is relatively small, which can maintain the natural structure and activity of biomolecules to the greatest extent. This is crucial for maintaining the efficacy of biological drugs, avoiding the loss of biological activity caused by excessive mechanical force in traditional separation methods, and providing high - quality raw materials for biopharmaceuticals.
- Suitable for Thermosensitive Drugs
Some drugs, especially biological preparations, are sensitive to temperature. The tubular centrifuge generates less heat during the separation process and will not cause the drug to deteriorate due to excessive temperature. When producing certain protein - based drugs, it can achieve efficient separation under mild conditions, ensuring the activity and stability of the drug.
Precautions in Application
Sample Pretreatment
- Filtering Large - Particle Impurities
Before feeding the sample into the tubular centrifuge, preliminary filtering must be carried out to remove large - particle impurities, such as tissue blocks in biological samples and insoluble solids in chemical samples. These large - particle impurities may clog the feeding pipeline of the centrifuge or damage the drum, affecting the normal operation of the equipment. Simple and effective methods such as screen filtering and coarse filters can be used for pretreatment.
- Adjusting Sample Properties
According to the characteristics of the sample, adjust its parameters such as pH value, temperature, and concentration to make it in a state suitable for separation by the tubular centrifuge. For example, for some biological samples, the sedimentation performance of the target components is better at a specific pH value; for some chemical samples, appropriately adjusting the temperature and concentration can improve the separation efficiency and product quality.
Equipment Maintenance and Upkeep
- Regularly Checking the Drum
The drum of the tubular centrifuge is subjected to a huge centrifugal force during high - speed rotation and is prone to wear. Regularly check the wear condition of the drum, promptly find and replace the severely worn drum to prevent safety accidents caused by drum rupture. At the same time, check the dynamic balance of the drum to ensure the stability of the centrifuge during operation.
- Maintaining the Driving Device and Seals
The driving device is a key component to ensure the normal operation of the centrifuge. Regularly lubricate and maintain it, check the working status of components such as the motor and belt, and promptly replace the damaged components. The good performance of the seals is crucial for preventing leakage. Regularly check and replace the seals to ensure the internal sealing of the centrifuge, avoiding material leakage and the entry of external impurities, which may affect drug quality.
Optimization of Operating Parameters
- Adjusting the Rotational Speed
According to the density, particle size of the sample, and separation requirements, reasonably adjust the rotational speed of the tubular centrifuge. An excessively high rotational speed may damage the target components in the sample, while an excessively low rotational speed will result in poor separation effects. Determine the optimal rotational speed through experiments to ensure both the separation effect and the maximum protection of drug components. For example, for biological samples with a relatively low density, appropriately reducing the rotational speed can avoid the impact of excessive shear force on biological activity; for chemical samples with a relatively high density, appropriately increasing the rotational speed can accelerate the separation speed.
- Controlling the Feeding Speed
An excessively fast feeding speed will make the material distribution in the centrifuge uneven, affecting the separation effect; an excessively slow feeding speed will reduce production efficiency. According to the processing capacity of the centrifuge and the properties of the sample, precisely control the feeding speed to ensure that the centrifuge operates in a stable working state. Generally, at the beginning of separation, the feeding speed can be appropriately reduced, and after the centrifuge operates stably, it can be gradually adjusted to an appropriate feeding speed.
Conclusion
With its high - efficiency separation performance, high - purity product output, and gentle separation process, the tubular centrifuge shows an irreplaceable important role in the pharmaceutical field. From biopharmaceuticals to chemical pharmaceuticals and then to traditional Chinese medicine pharmaceuticals, the tubular centrifuge provides key technical support for drug research and development and production, promoting the continuous development of the pharmaceutical industry. With the continuous progress of science and technology, the tubular centrifuge will continue to innovate and improve in terms of equipment performance optimization and intelligent control, and is expected to play a greater role in the pharmaceutical field, contributing to the production of more high - quality, safe, and effective drugs and ensuring the health and well - being of humanity.
-
Application Examples of Tubular Centrifuges in the Pharmaceutical Field
In Biopharmaceuticals
- Vaccine Production
During the production of influenza vaccines, hepatitis B vaccines, etc., the tubular centrifuge is used to separate virus particles from cell culture fluid or virus harvest fluid. By precisely controlling the centrifugation parameters, the virus is separated from impurities such as cell debris and medium components, obtaining a high - purity virus suspension, which provides high - quality raw materials for subsequent vaccine preparation processes. For example, after a well - known vaccine production enterprise adopted a tubular centrifuge, the vaccine production increased by 25%, and at the same time, the product purity and stability were significantly improved, reducing the incidence of adverse reactions of the vaccine.
- Monoclonal Antibody Production
In the industrial production of monoclonal antibodies, the tubular centrifuge performs preliminary clarification and fine separation on the cell culture fluid. First, most of the cell debris and impurities are removed, and then the antibody is further purified to increase the purity and concentration of the antibody. A biopharmaceutical company used a tubular centrifuge to increase the purity of monoclonal antibodies from 90% to 98% and the production efficiency by 30%, greatly reducing the production cost and improving the competitiveness of the product in the market.
In Chemical Pharmaceuticals
- API Purification
During the production of synthetic drugs, the tubular centrifuge is used to separate impurities and unreacted raw materials in the reaction products. For example, in the production of antibiotic APIs, the tubular centrifuge separates by - products, catalyst residues and other impurities in the synthetic reaction liquid to improve the purity of the API. When a pharmaceutical factory produced penicillin API, after using the tubular centrifuge, the product purity increased from 95% to 99%, meeting the strict quality requirements of the high - end market for APIs.
- Drug Intermediate Separation
During the preparation of drug intermediates, it is often necessary to separate complex mixtures. The tubular centrifuge can quickly and efficiently separate the target drug intermediates, providing pure raw materials for subsequent drug synthesis steps. In the production of antihypertensive drug intermediates, the tubular centrifuge achieved continuous separation, improving production efficiency and ensuring the quality stability of the intermediates.
In Traditional Chinese Medicine Pharmaceuticals
- Extraction of Active Ingredients from Traditional Chinese Medicine
In the production of traditional Chinese medicine preparations, the tubular centrifuge is used to separate active ingredients from traditional Chinese medicine extraction liquid. For example, during the preparation of ginkgo biloba extract, the traditional Chinese medicine extraction liquid is separated by a tubular centrifuge to remove impurities such as plant fibers and starch, and enrich active ingredients such as ginkgo flavonoids and terpene lactones. After using the tubular centrifuge, the purity of ginkgo biloba extract increased by 20%, and the yield of active ingredients increased by 15%, improving the quality and efficacy of traditional Chinese medicine products.
- Clarification of Traditional Chinese Medicine Injections
Traditional Chinese medicine injections have extremely high requirements for clarity and purity. The tubular centrifuge can effectively remove tiny particles and impurities in traditional Chinese medicine injections, improving the clarity and stability of the injections. When a traditional Chinese medicine pharmaceutical enterprise produced salvia miltiorrhiza injection, it used a tubular centrifuge for clarification treatment. The clarity of the product met the national standard, and the stability was significantly enhanced, reducing the risk of adverse reactions in clinical use.
(3) Gentle Separation Process
- Protection of Cell Integrity
Spirulina cells are relatively fragile. If they are subjected to excessive mechanical force during the separation process, the cells are likely to rupture, resulting in the loss of their nutritional components and biological activity. During the high - speed rotation of the tubular centrifuge, the shear force generated is relatively small, which can maintain the integrity of spirulina cells to the greatest extent. This enables the separated spirulina to retain its natural nutritional components and biological activity, providing high - quality raw materials for subsequent product development. For example, when used in the production of spirulina health products, the intact cell structure helps the human body better absorb the nutritional substances.
- Maintenance of Biological Activity
Many bioactive substances in spirulina, such as phycocyanin and γ - linolenic acid, are sensitive to factors such as temperature and shear force. The gentle separation process of the tubular centrifuge avoids the inactivation of bioactive substances caused by high temperature or high shear force. This is of great significance for the development of spirulina products with specific functions, such as antioxidant and immunomodulatory functional foods and health products.
IV. Application Examples
(1) Food and Health Product Fields
- Spirulina Powder Production
A large - scale spirulina production enterprise uses a tubular centrifuge for separation in the process of preparing spirulina powder. First, the spirulina cultivation liquid is fed into the tubular centrifuge, and after separation, a preliminarily concentrated spirulina slurry is obtained. Then, the spirulina slurry is further dried, crushed, etc., and finally, high - quality spirulina powder is obtained. After using the tubular centrifuge, the enterprise's spirulina powder production increased by 30%, and the product purity increased from the original 85% to over 95%. The competitiveness of the product in the market has been significantly enhanced.
- Spirulina Health Product Processing
When producing health products such as spirulina soft capsules, high - purity and well - active spirulina raw materials are required. A well - known health product company uses a tubular centrifuge to separate and purify spirulina, ensuring that the effective components in spirulina are not damaged during the processing. The spirulina health products produced by the company have a good reputation in the market, and consumers feedback that their efficacy is obvious, which is largely due to the high - quality raw materials provided by the tubular centrifuge.
(2) Cosmetics Field
- Application of Spirulina Extracts
Some cosmetics companies use spirulina extracts in the production of skin - care products to exert their moisturizing and antioxidant effects. Before extracting the effective components of spirulina, a tubular centrifuge is used to separate spirulina, removing impurities and moisture to obtain pure spirulina cells. The spirulina effective components extracted in this way have high purity and can better play their role in cosmetics. For example, a certain brand of spirulina moisturizing mask uses spirulina extracts processed by a tubular centrifuge, and the product's moisturizing effect and stability have been highly recognized by consumers.
(3) Bioenergy Research
- Processing of Spirulina Raw Materials for Biodiesel
In the research on using spirulina to prepare biodiesel, it is necessary to efficiently separate spirulina from the cultivation water and conduct subsequent processing. The tubular centrifuge can quickly separate spirulina, providing sufficient raw materials for biodiesel production. At the same time, due to its gentle separation process, it will not damage the oil components in spirulina, which is beneficial for subsequent oil extraction and conversion. A scientific research institution successfully improved the preparation efficiency and yield of biodiesel by using a tubular centrifuge to separate spirulina, providing a feasible technical solution for the application of spirulina in the bioenergy field.
V. Precautions in Application
(1) Sample Pretreatment
- Filtering of Large - Particle Impurities
Before feeding the spirulina suspension into the tubular centrifuge, preliminary filtering must be carried out to remove large - particle impurities such as debris in the cultivation pond and larger plankton. These large - particle impurities may clog the feeding pipeline of the centrifuge or damage the drum, affecting the normal operation of the centrifuge. Simple and effective methods such as screen filtering can be used for pretreatment.
- Adjustment of pH Value and Temperature
Under different pH values and temperature conditions, the stability and sedimentation performance of spirulina cells will vary. Before separation, it is necessary to adjust the pH value and temperature of the suspension to an appropriate range according to the characteristics of spirulina to improve the separation efficiency and product quality. For example, for some varieties of spirulina, when the pH value is adjusted to 7 - 8 and the temperature is controlled at 25 - 30°C, the separation effect is the best.
(2) Equipment Maintenance and Upkeep
- Regular Inspection of the Drum
The drum of the tubular centrifuge is subjected to a huge centrifugal force during high - speed rotation and is prone to wear. Regularly check the wear of the drum, and promptly replace the severely worn drum to prevent safety accidents caused by drum rupture. At the same time, check the dynamic balance of the drum to ensure the stability of the centrifuge during operation.
- Maintenance of the Driving Device and Seals
The driving device is a key component to ensure the normal operation of the centrifuge. It is necessary to regularly lubricate and maintain it, check the working status of components such as the motor and belt, and promptly replace damaged components. In addition, the good performance of the seals is crucial for preventing leakage. Regularly check and replace the seals to ensure the internal sealing of the centrifuge and avoid material leakage and the entry of external impurities.
(3) Optimization of Operating Parameters
- Adjustment of Rotational Speed
According to the concentration, density of the spirulina suspension, and separation requirements, reasonably adjust the rotational speed of the tubular centrifuge. An excessively high rotational speed may cause the rupture of spirulina cells, while an excessively low rotational speed will result in low separation efficiency. Determine the optimal rotational speed through experiments to ensure both the separation effect and the maximum protection of spirulina cells. For example, for a spirulina suspension with a relatively high concentration, the rotational speed can be appropriately increased to accelerate the separation speed; for a separation process with high requirements for cell integrity, the rotational speed needs to be reduced.
- Control of Feeding Speed
An excessively fast feeding speed will make the material distribution in the centrifuge uneven, affecting the separation effect; an excessively slow feeding speed will reduce production efficiency. According to the processing capacity of the centrifuge and the properties of the suspension, precisely control the feeding speed to ensure that the centrifuge operates in a stable working state. Generally, at the beginning of separation, the feeding speed can be appropriately reduced, and after the centrifuge operates stably, it can be gradually adjusted to an appropriate feeding speed.
VI. Conclusion
With its high - efficiency separation performance, high - purity product output, and gentle separation process, the tubular centrifuge demonstrates great advantages and broad application prospects in the field of spirulina separation. From the food and health product industries to the cosmetics and bioenergy fields, the tubular centrifuge provides key technical support for the industrial utilization of spirulina. With the continuous development of the spirulina industry and the increasing requirements for separation technology, the tubular centrifuge will continue to innovate and improve in terms of equipment performance optimization and intelligent control, further promoting the spirulina industry to develop in the direction of high - efficiency, high - quality, and sustainability, and making greater contributions to meeting people's needs for healthy and environmentally friendly products.
The working principle of the tubular centrifuge is based on the effect of centrifugal force, which creates a centrifugal force field within the high - speed rotating centrifuge tube when a mixture is placed in it. Under the action of centrifugal force, particles with higher density are flung towards the bottom of the centrifuge tube, while particles with lower density remain in the upper layer. By adjusting the magnitude of the centrifugal force and the duration of centrifugation, the separation of different particles can be achieved.
Detailed Photos
FAQ
Q1.What's your advantage? Why we choose you?
A:1) More than 50 years experience of centrifuge & separator production and R&D.We have the most professional techniques and team. More advantage in price.
2)Great production capacity Sustainable Supply . According to customer requirements, We support the customized include package.
3)We use Internationally renowned brand Inverter and PLC . Good quality materials and the best production process
Q2.What's the Payment?
A: T/T, Western Union, L/C, Ali Pay, etc
Q3.Are you a factory or trading company?
A:We are a professional manufacturer. We are warmly welcome clients from worldwide to visit our factory and cooperate with us.
Q4.How long is the warranty period ?
A:18 months after install .
){kind=link}